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Silica-based nanoarchitecture for an optimal combination of photothermal and chemodynamic therapy functions

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2144-2155 doi: 10.1007/s11705-023-2362-4

Abstract: This study introduces multifunctional silica nanoparticles that exhibit both high photothermal and chemodynamic therapeutic activities, in addition to luminescence. The activity of the silica nanoparticles is derived from their plasmonic properties, which are a result of infusing the silica nanoparticles with multiple Cu2–xS cores. This infusion process is facilitated by a recoating of the silica nanoparticles with a cationic surfactant. The key factors that enable the internal incorporation of the Cu2–xS cores and the external deposition of red-emitting carbon dots are identified. The Cu2–xS cores within the silica nanoparticles exhibit both self-boosting generation of reactive oxygen species and high photothermal conversion efficacy, which are essential for photothermal and chemodynamic activities. The silica nanoparticles’ small size (no more than 70 nm) and high colloidal stability are prerequisites for their cell internalization. The internalization of the red-emitting silica nanoparticles within cells is visualized using fluorescence microscopy techniques. The chemodynamic activity of the silica nanoparticles is associated with their dark cytotoxicity, and the mechanisms of cell death are evaluated using an apoptotic assay. The photothermal activity of the silica nanoparticles is demonstrated by significant cell death under near-infrared (1064 nm) irradiation.

Keywords： copper sulfide nanoparticles     chemodynamic therapy     photothermal therapy     carbon dots     silica nanoparticles    

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Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 12-23 doi: 10.1007/s11684-019-0685-9

Abstract:

Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the lastGiven the different mechanisms, oncologists have focused on determining whether ICIs-based combinationstrategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-linereview discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy

Keywords： gastrointestinal cancer     immune checkpoint inhibitor     combination therapy    

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A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 275-289 doi: 10.1007/s11684-022-0945-y

Abstract: carcinoma (NPC) and explored the anti-tumor effects of the novel pan-HER inhibitor HM781-36B, alone or in combinationThe pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic

Keywords： epidermal growth factor receptor     ErbB receptors     HM781-36B     nasopharyngeal carcinoma     molecular targeted therapy    

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Curcumin based combination therapy for anti-breast cancer: from

Sunhui Chen,Qiuling Liang,Shuping Xie,Ergang Liu,Zhili Yu,Lu Sun,Meong Cheol Shin,Seung Jin Lee,Huining He,Victor C. Yang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 3,   Pages 383-388 doi: 10.1007/s11705-016-1574-2

Abstract: resistance appears to be an inevitable problem of an increasing number of anticancer drugs in monotherapy, combinationdrug therapy has become a prosperous method to reduce the administered total drug dosages as well aschemo-resistance, can significantly facilitate its anti-cancer functions and improve therapeutic effects via combinationeffect, bovine serum albumin (BSA) nanoparticles were utilized as a carrier to deliver the selected drug combinationThis work could open up a new avenue on combination drug therapy and realization the clinical utility

Keywords： curcumin     sunitinib     synergistic effect     bovine serum albumin (BSA)     nano-carriers    

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerIn this work, the author focuses on the combination therapy of multiple immune checkpoints (does notinclude targeted therapy of oncogenes or chemotherapy), introduces the current progression of multipleimmune checkpoints and their related inhibitors, and discusses the advantages of combination therapy

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: survival pathway in GNAQ/11-mutant UM cells and showed a notable synergistic effect when applied in combination

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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New method for efficient control of hydrogen sulfide and methane in gravity sewers: Combination of NaOH

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 6, doi: 10.1007/s11783-021-1509-0

Abstract:

• The combination of NaOH and nitrite was used to control harmful gas

Keywords： Sewer corrosion     Sulfide control     Combination treatment     NaOH     Nitrite    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, althoughThese unanswered questions include: whether HT has a positive impact on breast cancer; whether risks of therapy

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Removal of virus aerosols by the combination of filtration and UV-C irradiation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1627-y

Abstract:

● The removal of virus aerosols by filtration and UV-C irradiation was proposed.

Keywords： Filtration system     UV-C irradiation     Virus aerosol     Public health     COVID-19    

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Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 165-172 doi: 10.1007/s11684-012-0196-4

Abstract: and intensity-modulated radiation therapy, proton therapy has yielded more promising outcomes in localCarbon therapy in Japan showed even more promising results than proton therapy.The non-invasive nature of particle therapy affords more patients with chances to receive and benefitParticle therapy is gradually getting attention from the oncology community.However, the cost of particle therapy facilities has limited the worldwide use of this technology.

Keywords： radiation therapy     particle therapy     proton     carbon     cancer    

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Studies on Combination Evaluation Methods Based on Nature Differenc

Chen Yantai,Chen Guohong,Li Meijuan

Strategic Study of CAE 2005, Volume 7, Issue 8,   Pages 56-59

Abstract: Secondly, it puts forward one new combination evaluation method , in order to solve the problem of inconsistencies

Keywords： evaluation methods with different nature     combination evaluation     re-combination    

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Passive antibody therapy in emerging infectious diseases

Frontiers of Medicine doi: 10.1007/s11684-023-1021-y

Abstract: In addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights

Keywords： SARS-CoV-2     COVID-19     convalescent plasma     hyperimmunoglobulin     neutralizing monoclonal antibodies    

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Adsorption in combination with ozonation for the treatment of textile waste water: a critical review

Shraddha Khamparia,Dipika Kaur Jaspal

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 1, doi: 10.1007/s11783-017-0899-5

Abstract: A combination of adsorption with ozonation proved best for dye removal.The review summarizes dye removal study by a combination of ozonation and adsorption methods.

Keywords： Adsorption     Ozonation     Catalytic Ozonation     Textile dyes     Mineralization    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: rationale, the intriguing question is why cancers are insensitive or not responsive to mTOR-targeted cancer therapyERK, and Mnk/eIF4E survival signaling pathways that compromise the efficacy of rapalog-based cancer therapyThese new findings may also offer us the opportunity to rationally utilize mTOR inhibitors in cancer therapy

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF.Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF wereThe efficacy and safety of targeted therapy were compared with those of other systemic therapy optionsTargeted therapy does not provide considerable advantages in efficacy and safety over other medical treatmentsstudies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy

Keywords： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Title Author Date Type Operation

Silica-based nanoarchitecture for an optimal combination of photothermal and chemodynamic therapy functions

Journal Article

Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Journal Article

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

Journal Article

Curcumin based combination therapy for anti-breast cancer: from

Sunhui Chen,Qiuling Liang,Shuping Xie,Ergang Liu,Zhili Yu,Lu Sun,Meong Cheol Shin,Seung Jin Lee,Huining He,Victor C. Yang

Journal Article

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma

Journal Article

New method for efficient control of hydrogen sulfide and methane in gravity sewers: Combination of NaOH

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Removal of virus aerosols by the combination of filtration and UV-C irradiation

Journal Article

Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Journal Article

Studies on Combination Evaluation Methods Based on Nature Differenc

Chen Yantai,Chen Guohong,Li Meijuan

Journal Article

Passive antibody therapy in emerging infectious diseases

Journal Article

Adsorption in combination with ozonation for the treatment of textile waste water: a critical review

Shraddha Khamparia,Dipika Kaur Jaspal

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article